Regulation of phospholipase C-gamma2 networks in B lymphocytes
- PMID: 16227088
- DOI: 10.1016/S0065-2776(05)88003-4
Regulation of phospholipase C-gamma2 networks in B lymphocytes
Abstract
The modulation of inositol-1,4,5-trisphosphate (IP3), a product of phospholipase C (PLC) activity, is one of a common signaling mechanism used in many biological systems. B lymphocytes also rely on IP3 and subsequent calcium signaling to ensure appropriate developmental outcomes, as well as antigen-specific responses. In establishing the optimal intensity and duration of the PLC-gamma activity, an important role has emerged for adaptor molecules, which direct the appropriate subcellular localization of PLC-gamma and induce its conformational changes. Generated IP3 binds to IP3 receptors located on the endoplasmic reticulum (ER), which in turn is essential for triggering calcium release from the ER and subsequent entry of extracellular calcium by so-called Ca2+ entry channels. Recent data has begun to shed new light on the connection between the calcium release and the influx of extracellular calcium, and the molecular identity of the Ca2+ entry channels.
Similar articles
-
Regulation of the phospholipase C-gamma2 pathway in B cells.Immunol Rev. 2000 Aug;176:19-29. doi: 10.1034/j.1600-065x.2000.00605.x. Immunol Rev. 2000. PMID: 11043765 Review.
-
Ca(2+) signaling in antigen receptor-activated B lymphocytes.Immunol Rev. 2007 Aug;218:235-46. doi: 10.1111/j.1600-065X.2007.00539.x. Immunol Rev. 2007. PMID: 17624956 Review.
-
Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Immunology. 2004 Aug;112(4):575-82. doi: 10.1111/j.1365-2567.2004.01918.x. Immunology. 2004. PMID: 15270728 Free PMC article.
-
Rapid functional assays of recombinant IP3 receptors.Cell Calcium. 2005 Jul;38(1):45-51. doi: 10.1016/j.ceca.2005.04.001. Cell Calcium. 2005. PMID: 15963563
-
Differential Regulation of Multiple Steps in Inositol 1,4,5-Trisphosphate Signaling by Protein Kinase C Shapes Hormone-stimulated Ca2+ Oscillations.J Biol Chem. 2015 Jul 24;290(30):18519-33. doi: 10.1074/jbc.M115.657767. Epub 2015 Jun 15. J Biol Chem. 2015. PMID: 26078455 Free PMC article.
Cited by
-
The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.J Biol Chem. 2016 Oct 14;291(42):22136-22148. doi: 10.1074/jbc.M116.746842. Epub 2016 Aug 19. J Biol Chem. 2016. PMID: 27542411 Free PMC article.
-
Molecular underpinning of B-cell anergy.Immunol Rev. 2010 Sep;237(1):249-63. doi: 10.1111/j.1600-065X.2010.00936.x. Immunol Rev. 2010. PMID: 20727040 Free PMC article. Review.
-
Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.J Immunol. 2015 Aug 1;195(3):853-64. doi: 10.4049/jimmunol.1403114. Epub 2015 Jun 24. J Immunol. 2015. PMID: 26109644 Free PMC article.
-
Echinacea-induced cytosolic Ca2+ elevation in HEK293.BMC Complement Altern Med. 2010 Nov 23;10:72. doi: 10.1186/1472-6882-10-72. BMC Complement Altern Med. 2010. PMID: 21092239 Free PMC article.
-
Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinase.J Biol Chem. 2009 Jul 24;284(30):20070-8. doi: 10.1074/jbc.M109.016865. Epub 2009 Jun 3. J Biol Chem. 2009. PMID: 19494109 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
