doi: 10.1007/s11908-005-0050-9.
The HIV infection and immune activation: "to fight and burn"
Affiliations
- PMID: 16225786
- DOI: 10.1007/s11908-005-0050-9
Item in Clipboard
The HIV infection and immune activation: "to fight and burn"
Curr Infect Dis Rep.
2005 Nov.
Abstract
Immune activation, a normal immune reaction to pathogens, is now recognized as a major driving force of the CD4 T-cell depletion and immune disorders caused by HIV. By contrast, the natural hosts of its ancestor virus, simian immunodeficiency virus, have adapted to this virus by blocking immune activation and remaining healthy. This review will focus on evidence demonstrating how immune activation associated with HIV infection exhausts immune defenses to HIV as well as the immune system, thus leading to immunosenescence and immunodeficiency, and how treatment can disrupt this vicious and ultimately fatal circle.
Similar articles
-
CD4+ T-cell depletion in HIV infection: killed by friendly fire?Curr HIV/AIDS Rep. 2005 Feb;2(1):16-23. doi: 10.1007/s11904-996-0004-3. Curr HIV/AIDS Rep. 2005. PMID: 16091244 Review.
-
Immune activation in HIV infection: what can the natural hosts of simian immunodeficiency virus teach us?Curr Opin HIV AIDS. 2016 Mar;11(2):201-8. doi: 10.1097/COH.0000000000000238. Curr Opin HIV AIDS. 2016. PMID: 26845673 Review.
-
Chronic alcohol increases CD8+ T-cell immunosenescence in simian immunodeficiency virus-infected rhesus macaques.Alcohol. 2015 Dec;49(8):759-65. doi: 10.1016/j.alcohol.2015.09.003. Epub 2015 Oct 27. Alcohol. 2015. PMID: 26603633 Free PMC article.
-
On the Death Rate of Abortively Infected Cells: Estimation from Simian-Human Immunodeficiency Virus Infection.J Virol. 2017 Aug 24;91(18):e00352-17. doi: 10.1128/JVI.00352-17. Print 2017 Sep 15. J Virol. 2017. PMID: 28679753 Free PMC article.
-
CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections.J Virol. 2017 Jan 31;91(4):e01626-16. doi: 10.1128/JVI.01626-16. Print 2017 Feb 15. J Virol. 2017. PMID: 27903799 Free PMC article.
Cited by
-
Inflammatory and Immune Mechanisms for Atherosclerotic Cardiovascular Disease in HIV.Int J Mol Sci. 2024 Jul 1;25(13):7266. doi: 10.3390/ijms25137266. Int J Mol Sci. 2024. PMID: 39000373 Free PMC article. Review.
-
Effect of Immunomodulating Adjuvant Dzherelo (Immunoxel) in HIV Infected Patients Receiving Standard Antiretroviral Therapy.Open Virol J. 2009 May 5;3:31-6. doi: 10.2174/1874357900903010031. Open Virol J. 2009. PMID: 19572055 Free PMC article.
-
Taking stock of infections and antibiotic resistance in the elderly and long-term care facilities: A survey of existing and upcoming challenges.Eur J Microbiol Immunol (Bp). 2011 Sep;1(3):190-7. doi: 10.1556/EuJMI.1.2011.3.2. Epub 2011 Sep 9. Eur J Microbiol Immunol (Bp). 2011. PMID: 24516724 Free PMC article. Review.
-
Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages.Sci Rep. 2016 Oct 13;6:34752. doi: 10.1038/srep34752. Sci Rep. 2016. PMID: 27734899 Free PMC article.
-
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.J Exp Med. 2007 Sep 3;204(9):2171-85. doi: 10.1084/jem.20070567. Epub 2007 Aug 27. J Exp Med. 2007. PMID: 17724130 Free PMC article.
References
LinkOut - more resources
Full Text Sources
Research Materials