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. 1992 May;37(1):61-6.
doi: 10.1002/jmv.1890370111.

Fine specificity of the humoral immune response to HIV-1 GP160 in HIV-1 infected individuals from Tanzania

W M Nkya  1 , R Q Warren, H Wolf, C W Hendrix, J Tesha, R R Redfield, G P Melcher, D S Burke, P Kanda, R C Kennedy
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Fine specificity of the humoral immune response to HIV-1 GP160 in HIV-1 infected individuals from Tanzania

W M Nkya et al. J Med Virol. 1992 May.

Abstract

A total of 160 sera from HIV-1 infected individuals from Tanzania were examined for their fine specificity characteristics relative to 9 synthetic peptides that define HIV-1 gp160 epitopes. Immunorecessive and immunodominant epitopes were identified in both gp120 and gp41 based on serologic reactivity of these HIV-1 infected sera. A significant difference in fine specificity among HIV-1 infected individuals from Tanzania and the United States was observed for an immunodominant gp41 epitope. No significant differences in reactivity among asymptomatic vs. symptomatic HIV-1 infected individuals were detected for the selected HIV-1 gp160 epitopes defined by these peptides. The majority of sera from HIV-1 infected Tanzanians contained antibodies that recognized a peptide corresponding to the V3 region of gp120 from the HIV-1 MN isolate. These data suggest that regional isolates of HIV-1 may exist in Tanzania that differ from HIV-1 isolated in the United States. However, based on serology, HIV-1 isolates exhibiting sequences with HIV-1 MN V3 similarity may also be prevalent in Tanzania. The results of this study may be useful for the design of more effective AIDS diagnostic and therapeutic products for use worldwide.

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