Review
doi: 10.1016/j.tcm.2005.06.001.
Is there a role for cardiomyocyte toll-like receptor 4 in endotoxemia?
Affiliations
- PMID: 16165010
- DOI: 10.1016/j.tcm.2005.06.001
Item in Clipboard
Review
Is there a role for cardiomyocyte toll-like receptor 4 in endotoxemia?
Trends Cardiovasc Med.
2005 Jul.
Abstract
Lipopolysaccharide (LPS) is thought to be an important molecule in myocardial depression in sepsis. Toll-like receptor 4 (TLR4), the lipopolysaccharide receptor, is known to underlie these responses. Because TLR4 is expressed on both cardiac myocytes and immune cells, it is unclear as to which cell type is responsible for myocyte depression. In this article, we present evidence that the early response is likely related to TLR4 on immune cells and most likely macrophages, whereas the more delayed response may involve various immune cells as well as myocytes.
Similar articles
-
Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia.Circ Res. 2004 Oct 1;95(7):700-7. doi: 10.1161/01.RES.0000144175.70140.8c. Epub 2004 Sep 9. Circ Res. 2004. PMID: 15358664
-
The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway.J Immunol. 2010 Feb 1;184(3):1492-8. doi: 10.4049/jimmunol.0902660. Epub 2009 Dec 18. J Immunol. 2010. PMID: 20028656
-
Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes.Cardiovasc Res. 2007 Jul 15;75(2):408-16. doi: 10.1016/j.cardiores.2007.03.020. Epub 2007 Mar 30. Cardiovasc Res. 2007. PMID: 17466955
-
Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility.Antioxid Redox Signal. 2011 Oct 1;15(7):1895-909. doi: 10.1089/ars.2010.3728. Epub 2011 Apr 21. Antioxid Redox Signal. 2011. PMID: 21126202 Review.
-
[The role of LPS/TLR4 interaction on the pathogenesis of acute on chronic liver failure].Zhonghua Gan Zang Bing Za Zhi. 2010 Jan;18(1):78-80. doi: 10.3760/cma.j.issn.1007-3418.2010.01.024. Zhonghua Gan Zang Bing Za Zhi. 2010. PMID: 20128982 Review. Chinese. No abstract available.
Cited by
-
Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia.Crit Care. 2014 Sep 11;18(5):527. doi: 10.1186/s13054-014-0527-8. Crit Care. 2014. PMID: 25209241 Free PMC article.
-
Betaine inhibits toll-like receptor 4 expression in rats with ethanol-induced liver injury.World J Gastroenterol. 2010 Feb 21;16(7):897-903. doi: 10.3748/wjg.v16.i7.897. World J Gastroenterol. 2010. PMID: 20143470 Free PMC article.
-
The Role of Endotoxin in the Setting of Cardiorenal Syndrome Type 5.Cardiorenal Med. 2017 Oct;7(4):276-283. doi: 10.1159/000475846. Epub 2017 Jun 24. Cardiorenal Med. 2017. PMID: 29118766 Free PMC article. Review.
-
Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments.Front Immunol. 2017 Aug 24;8:1021. doi: 10.3389/fimmu.2017.01021. eCollection 2017. Front Immunol. 2017. PMID: 28970829 Free PMC article. Review.
-
Cyclic stretch enhances the expression of toll-like receptor 4 gene in cultured cardiomyocytes via p38 MAP kinase and NF-kappaB pathway.J Biomed Sci. 2010 Mar 5;17(1):15. doi: 10.1186/1423-0127-17-15. J Biomed Sci. 2010. PMID: 20202224 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
