Upstream stimulating factors: highly versatile stress-responsive transcription factors
- PMID: 16162174
- DOI: 10.1111/j.1600-0749.2005.00262.x
Upstream stimulating factors: highly versatile stress-responsive transcription factors
Abstract
Upstream stimulating factors (USF), USF-1 and USF-2, are members of the eucaryotic evolutionary conserved basic-Helix-Loop-Helix-Leucine Zipper transcription factor family. They interact with high affinity to cognate E-box regulatory elements (CANNTG), which are largely represented across the whole genome in eucaryotes. The ubiquitously expressed USF-transcription factors participate in distinct transcriptional processes, mediating recruitment of chromatin remodelling enzymes and interacting with co-activators and members of the transcription pre-initiation complex. Results obtained from both cell lines and knock-out mice indicates that USF factors are key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism, and in melanocytes USF-1 has been implicated as a key UV-activated regulator of genes associated with pigmentation. This review will focus on general characteristics of the USF-transcription factors and their place in some regulatory networks.
Similar articles
-
[USF as a key regulatory element of gene expression].Med Sci (Paris). 2006 Jan;22(1):62-7. doi: 10.1051/medsci/200622162. Med Sci (Paris). 2006. PMID: 16386222 Review. French.
-
The UV responsive elements in the human mimecan promoter: a functional characterization.Mol Vis. 2003 Jan 2;9:1-9. Mol Vis. 2003. PMID: 12533723
-
The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells.Mol Endocrinol. 1998 May;12(5):714-26. doi: 10.1210/mend.12.5.0100. Mol Endocrinol. 1998. PMID: 9605934
-
The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.EMBO J. 2001 Sep 3;20(17):5022-31. doi: 10.1093/emboj/20.17.5022. EMBO J. 2001. PMID: 11532965 Free PMC article.
-
[From the glycogenic function of the liver to gene regulation by glucose].C R Seances Soc Biol Fil. 1998;192(5):813-27. C R Seances Soc Biol Fil. 1998. PMID: 9871795 Review. French.
Cited by
-
Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways.Exp Mol Med. 2013 Apr 5;45(4):e17. doi: 10.1038/emm.2013.20. Exp Mol Med. 2013. PMID: 23559126 Free PMC article.
-
USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator.PLoS Biol. 2012;10(3):e1001277. doi: 10.1371/journal.pbio.1001277. Epub 2012 Mar 6. PLoS Biol. 2012. PMID: 22412349 Free PMC article.
-
High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells.J Cell Biochem. 2008 Apr 15;103(6):1952-61. doi: 10.1002/jcb.21585. J Cell Biochem. 2008. PMID: 17955499 Free PMC article.
-
Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells.Am J Physiol Renal Physiol. 2010 Jul;299(1):F121-7. doi: 10.1152/ajprenal.00074.2010. Epub 2010 Apr 21. Am J Physiol Renal Physiol. 2010. PMID: 20410211 Free PMC article.
-
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness.Genes Dev. 2006 Dec 15;20(24):3426-39. doi: 10.1101/gad.406406. Genes Dev. 2006. PMID: 17182868 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
