Statistical signals in bioinformatics

doi:10.1073/pnas.0501804102

Review

. 2005 Sep 20;102(38):13355-62.

doi: 10.1073/pnas.0501804102. Epub 2005 Sep 12.

Statistical signals in bioinformatics

Samuel Karlin¹

Affiliations

PMID: 16157888
PMCID: PMC1224616
DOI: 10.1073/pnas.0501804102

Review

Statistical signals in bioinformatics

Samuel Karlin. Proc Natl Acad Sci U S A. 2005.

. 2005 Sep 20;102(38):13355-62.

doi: 10.1073/pnas.0501804102. Epub 2005 Sep 12.

Author

Samuel Karlin¹

Affiliation

¹ Department of Mathematics, Stanford University, Stanford, CA 94305-2125, USA. karlin@math.stanford.edu

PMID: 16157888
PMCID: PMC1224616
DOI: 10.1073/pnas.0501804102

Abstract

The Arthur M. Sackler Colloquium of the National Academy of Sciences, "Frontiers in Bioinformatics: Unsolved Problems and Challenges," organized by David Eisenberg, Russ Altman, and myself, was held October 15-17, 2004, to provide a forum for discussing concepts and methods in bioinformatics serving the biological and medical sciences. The deluge of genomic and proteomic data in the last two decades has driven the creation of tools that search and analyze biomolecular sequences and structures. Bioinformatics is highly interdisciplinary, using knowledge from mathematics, statistics, computer science, biology, medicine, physics, chemistry, and engineering.

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Figures

**Fig. 1.**
High-scoring assignments to identify transmembrane protein segments. A, experimentally established transmembrane tracts.

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References

1. Pace, N. R. (1997) Science 276, 734-740. - PubMed
1. Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., et al. (2004) Science 304, 66-74. - PubMed
1. Zeidner, G., Preston, C. M., Delong, E. F., Massana, R., Post, A. F., Scanlan, D. J. & Beja, O. (2003) Environ. Microbiol. 5, 212-216. - PubMed
1. Beja, O., Aravind, L., Koonin, E. V., Suzuki, M. T., Hadd, A., Nguyen, L. P., Jovanovich, S. B., Gates, C. M., Feldman, R. A., Spudich, J. L., et al. (2000) Science 289, 1902-1906. - PubMed
1. Lepp, P. W., Brinig, M. M., Ouverney, C. C., Palm, K., Armitage, G. C. & Relman, D. A. (2004) Proc. Natl. Acad. Sci. USA 101, 6176-6181. - PMC - PubMed

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[1] Pace, N. R. (1997) Science 276, 734-740. - PubMed

[2] Pace, N. R. (1997) Science 276, 734-740. - PubMed

[3] Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., et al. (2004) Science 304, 66-74. - PubMed

[4] Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., et al. (2004) Science 304, 66-74. - PubMed

[5] Zeidner, G., Preston, C. M., Delong, E. F., Massana, R., Post, A. F., Scanlan, D. J. & Beja, O. (2003) Environ. Microbiol. 5, 212-216. - PubMed

[6] Zeidner, G., Preston, C. M., Delong, E. F., Massana, R., Post, A. F., Scanlan, D. J. & Beja, O. (2003) Environ. Microbiol. 5, 212-216. - PubMed

[7] Beja, O., Aravind, L., Koonin, E. V., Suzuki, M. T., Hadd, A., Nguyen, L. P., Jovanovich, S. B., Gates, C. M., Feldman, R. A., Spudich, J. L., et al. (2000) Science 289, 1902-1906. - PubMed

[8] Beja, O., Aravind, L., Koonin, E. V., Suzuki, M. T., Hadd, A., Nguyen, L. P., Jovanovich, S. B., Gates, C. M., Feldman, R. A., Spudich, J. L., et al. (2000) Science 289, 1902-1906. - PubMed

[9] Lepp, P. W., Brinig, M. M., Ouverney, C. C., Palm, K., Armitage, G. C. & Relman, D. A. (2004) Proc. Natl. Acad. Sci. USA 101, 6176-6181. - PMC - PubMed

[10] Lepp, P. W., Brinig, M. M., Ouverney, C. C., Palm, K., Armitage, G. C. & Relman, D. A. (2004) Proc. Natl. Acad. Sci. USA 101, 6176-6181. - PMC - PubMed

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Statistical signals in bioinformatics

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Statistical signals in bioinformatics

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