Review
doi: 10.1016/j.semcdb.2005.03.001.
Epub 2005 Apr 22.
The HIF pathway in cancer
Affiliations
- PMID: 16144689
- DOI: 10.1016/j.semcdb.2005.03.001
Item in Clipboard
Review
The HIF pathway in cancer
Semin Cell Dev Biol.
2005 Aug-Oct.
Abstract
The transcription factor hypoxia-inducible factor-1 (HIF) is commonly activated in cancer. This has major effects on gene expression, and is important in tumor angiogenesis. Besides being activated by low oxygen, genetic events in cancer contribute to activating HIF. Most striking is that loss of function of the VHL tumour suppressor protein results in constitutive activation of the HIF pathway. An important aim is to define the contribution of HIF activation to the evolution of different cancers, and its potential as a therapeutic target.
Similar articles
-
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.Eur J Med Chem. 2012 Mar;49:24-40. doi: 10.1016/j.ejmech.2012.01.033. Epub 2012 Jan 24. Eur J Med Chem. 2012. PMID: 22305612 Review.
-
Cellular redox status regulates hypoxia inducible factor-1 activity. Role in tumour development.J Exp Clin Cancer Res. 2007 Mar;26(1):39-50. J Exp Clin Cancer Res. 2007. PMID: 17550131 Review.
-
Targeting the hypoxia-inducible factor (HIF) pathway in cancer.Expert Rev Mol Med. 2009 Aug 27;11:e26. doi: 10.1017/S1462399409001173. Expert Rev Mol Med. 2009. PMID: 19709449 Review.
-
Inhibitors of hypoxia-inducible factor-1 signaling.Curr Opin Investig Drugs. 2006 Dec;7(12):1067-76. Curr Opin Investig Drugs. 2006. PMID: 17209524 Review.
-
Evaluation of HIF-1 inhibitors as anticancer agents.Drug Discov Today. 2007 Oct;12(19-20):853-9. doi: 10.1016/j.drudis.2007.08.006. Epub 2007 Sep 18. Drug Discov Today. 2007. PMID: 17933687 Review.
Cited by
-
Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma.Chin J Cancer. 2012 Apr;31(4):197-206. doi: 10.5732/cjc.011.10283. Epub 2012 Jan 9. Chin J Cancer. 2012. PMID: 22237040 Free PMC article.
-
Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility.Oncogene. 2011 Mar 10;30(10):1159-73. doi: 10.1038/onc.2010.497. Epub 2010 Nov 8. Oncogene. 2011. PMID: 21057536 Free PMC article.
-
The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling.J Biol Chem. 2018 Apr 13;293(15):5659-5667. doi: 10.1074/jbc.RA117.001194. Epub 2018 Feb 23. J Biol Chem. 2018. PMID: 29475939 Free PMC article.
-
On-chip, cell-based microarray immunofluorescence assay for high-throughput analysis of target proteins.Anal Chem. 2008 Sep 1;80(17):6633-9. doi: 10.1021/ac800848j. Epub 2008 Jul 26. Anal Chem. 2008. PMID: 18656951 Free PMC article.
-
Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy.Clin Epigenetics. 2011 Dec 5;3(1):9. doi: 10.1186/1868-7083-3-9. Clin Epigenetics. 2011. PMID: 22414300 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
