Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency
- PMID: 16141399
- DOI: 10.1161/01.ATV.0000184783.04864.9f
Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency
Abstract
Macrophage apoptosis occurs throughout all stages of atherosclerosis, yet new findings in vivo suggest that the consequences of this event may be very different in early versus late atherosclerotic lesions. In early lesions, where phagocytic clearance of apoptotic cells appears to be efficient, macrophage apoptosis is associated with diminished lesion cellularity and decreased lesion progression. In late lesions, however, a number of factors may contribute to defective phagocytic clearance of apoptotic macrophages, leading to secondary necrosis of these cells and a proinflammatory response. The cumulative effect of these late lesional events is generation of the necrotic core, which, in concert with proatherogenic effects of residual surviving macrophages, promotes further inflammation, plaque instability, and thrombosis. Thus, the ability or lack thereof of lesional phagocytes to safely clear apoptotic macrophages may be an important determinant of acute atherothrombotic clinical events. Further understanding of the mechanisms involved in macrophage apoptosis and phagocytic clearance might lead to novel therapeutic strategies directed against the progression of advanced plaques.
Similar articles
-
Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.Circulation. 2009 Apr 7;119(13):1795-804. doi: 10.1161/CIRCULATIONAHA.108.806158. Epub 2009 Mar 23. Circulation. 2009. PMID: 19307478
-
Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice.Circulation. 2007 Nov 6;116(19):2182-90. doi: 10.1161/CIRCULATIONAHA.107.698852. Epub 2007 Oct 22. Circulation. 2007. PMID: 17967777
-
[New insights into the etiopathogenesis of atherosclerosis and atherothrombosis].Bull Mem Acad R Med Belg. 2006;161(3-4):213-25; discussion 226-7. Bull Mem Acad R Med Belg. 2006. PMID: 17172227 Review. French.
-
Apoptosis and efferocytosis in mouse models of atherosclerosis.Curr Drug Targets. 2007 Dec;8(12):1288-96. doi: 10.2174/138945007783220623. Curr Drug Targets. 2007. PMID: 18220705 Review.
-
Differential sensitivity to apoptosis among the cells that contribute to the atherosclerotic disease.Biochem Biophys Res Commun. 2007 Nov 16;363(2):444-50. doi: 10.1016/j.bbrc.2007.09.004. Epub 2007 Sep 11. Biochem Biophys Res Commun. 2007. PMID: 17884013
Cited by
-
A bibliometric analysis of endoplasmic reticulum stress and atherosclerosis.Front Physiol. 2024 Jun 11;15:1392454. doi: 10.3389/fphys.2024.1392454. eCollection 2024. Front Physiol. 2024. PMID: 38938744 Free PMC article. Review.
-
ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity.Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):4-12. doi: 10.1161/ATVBAHA.112.252056. Epub 2012 Nov 8. Arterioscler Thromb Vasc Biol. 2013. PMID: 23139293 Free PMC article.
-
Changes in transcriptome of macrophages in atherosclerosis.J Cell Mol Med. 2015 Jun;19(6):1163-73. doi: 10.1111/jcmm.12591. Epub 2015 May 13. J Cell Mol Med. 2015. PMID: 25973901 Free PMC article. Review.
-
Soat1 mediates the mouse strain effects on cholesterol loading-induced endoplasmic reticulum stress and CHOP expression in macrophages.Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Jan;1866(1):158825. doi: 10.1016/j.bbalip.2020.158825. Epub 2020 Oct 6. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33031913 Free PMC article.
-
Size-selective uptake of colloidal low density lipoprotein aggregates by cultured white blood cells.J Colloid Interface Sci. 2010 Oct 15;350(2):494-501. doi: 10.1016/j.jcis.2010.06.059. Epub 2010 Jul 3. J Colloid Interface Sci. 2010. PMID: 20667542 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
