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. 2005 Aug 31;46(4):484-90.
doi: 10.3349/ymj.2005.46.4.484.

Characteristics of type 2 diabetes in terms of insulin resistance in Korea

Jong-Suk Park  1 , Chul-Sik Kim, Joo-Young Nam, Dol-Mi Kim, Min-Ho Jo, Jina Park, Chul-Woo Ahn, Bong-Soo Cha, Sung-Kil Lim, Kyung-Rae Kim, Hyun-Chul Lee, Kap-Bum Huh
Affiliations

Characteristics of type 2 diabetes in terms of insulin resistance in Korea

Jong-Suk Park et al. Yonsei Med J. .

Abstract

The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI (insulin sensitivity index), and the tertile I (the insulin- resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p < 0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p < 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p < 0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.

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