Review
doi: 10.2337/diacare.28.9.2289.
The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
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- PMID: 16123508
- DOI: 10.2337/diacare.28.9.2289
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Review
The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes
Diabetes Care.
2005 Sep.
Abstract
The term "metabolic syndrome" refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance. Since the term is widely used in research and clinical practice, we undertook an extensive review of the literature in relation to the syndrome's definition, underlying pathogenesis, and association with CVD and to the goals and impact of treatment. While there is no question that certain CVD risk factors are prone to cluster, we found that the metabolic syndrome has been imprecisely defined, there is a lack of certainty regarding its pathogenesis, and there is considerable doubt regarding its value as a CVD risk marker. Our analysis indicates that too much critically important information is missing to warrant its designation as a "syndrome." Until much needed research is completed, clinicians should evaluate and treat all CVD risk factors without regard to whether a patient meets the criteria for diagnosis of the "metabolic syndrome."
Comment in
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The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et al.Diabetes Care. 2006 Jan;29(1):175-6; author reply 177-8. Diabetes Care. 2006. PMID: 16419352 No abstract available.
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The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et al.Diabetes Care. 2006 Jan;29(1):176; author reply 177-8. Diabetes Care. 2006. PMID: 16419353 No abstract available.
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The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et al.Diabetes Care. 2006 Jan;29(1):176-7; author reply 177-8. doi: 10.2337/diacare.29.1.176-a. Diabetes Care. 2006. PMID: 16419354 No abstract available.
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The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes: response to Kahn et al.Diabetes Care. 2006 Jan;29(1):177; author reply 177-8. doi: 10.2337/diacare.29.1.177. Diabetes Care. 2006. PMID: 16419355 No abstract available.
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Metabolic syndrome or "central obesity syndrome"?Diabetes Care. 2006 Mar;29(3):752. doi: 10.2337/diacare.29.03.06.dc05-2392. Diabetes Care. 2006. PMID: 16505547 No abstract available.
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Does the metabolic syndrome exist?Diabetes Care. 2006 Jul;29(7):1689-92; discussion 1693-6. doi: 10.2337/dc05-2307. Diabetes Care. 2006. PMID: 16801603 No abstract available.
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