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Review
. 2005 Aug 18;436(7053):967-72.
doi: 10.1038/nature04082.

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

Jordan J Feld  1 , Jay H Hoofnagle
Affiliations
Review

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

Jordan J Feld et al. Nature. .

Abstract

Since the identification of the hepatitis C virus, great strides have been made in the development of an antiviral therapy. As a crucial mediator of the innate antiviral immune response, interferon-alpha (IFN-alpha) was a natural choice for treatment. Whereas treatment with IFN-alpha alone achieved only modest success, the addition of the broad-spectrum antiviral agent ribavirin greatly improved responses. However, half of the infected individuals with chronic disease do not achieve sustained clearance of hepatitis C virus. To optimize current therapeutic strategies and to develop new therapies, a better understanding of the mechanism of action of IFN and ribavirin will be essential.

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