Review
doi: 10.1139/o05-119.
Lsh, a guardian of heterochromatin at repeat elements
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- PMID: 16094458
- DOI: 10.1139/o05-119
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Review
Lsh, a guardian of heterochromatin at repeat elements
Biochem Cell Biol.
2005 Aug.
Abstract
Lymphoid-specific helicase (Lsh) is a crucial factor for normal embryonic development; targeted deletion of Lsh is lethal. Lsh belongs to a family of chromatin-remodeling proteins and is closely associated with pericentromeric heterochromatin. Lsh deficiency leads to abnormal heterochromatin organization, with a loss of DNA methylation, and an altered pattern of histone-tail acetylation and methylation. As a functional consequence of perturbed heterochromatin, aberrant reactivation of parasitic retroviral elements in the genome and abnormal mitosis with amplified centrosomes and genomic instability were observed. Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function.
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