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Review
. 2005 Aug;6(8):610-21.
doi: 10.1038/nrm1701.

Ubiquitin-binding domains

Linda Hicke  1 , Heidi L Schubert, Christopher P Hill
Affiliations
Review

Ubiquitin-binding domains

Linda Hicke et al. Nat Rev Mol Cell Biol. 2005 Aug.

Abstract

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-covalently bind to ubiquitin. These recently discovered motifs interpret and transmit information conferred by protein ubiquitylation to control various cellular events. Detailed molecular structures are known for a number of UBDs, but to understand their mechanism of action, we also need to know how binding specificity is determined, how ubiquitin binding is regulated, and the function of UBDs in the context of full-length proteins. Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes.

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