Review
doi: 10.1038/nri1669.
Structure and function of the spleen
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- PMID: 16056254
- DOI: 10.1038/nri1669
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Review
Structure and function of the spleen
Nat Rev Immunol.
2005 Aug.
Abstract
The spleen combines the innate and adaptive immune system in a uniquely organized way. The structure of the spleen enables it to remove older erythrocytes from the circulation and leads to the efficient removal of blood-borne microorganisms and cellular debris. This function, in combination with a highly organized lymphoid compartment, makes the spleen the most important organ for antibacterial and antifungal immune reactivity. A better understanding of the function of this complex organ has been gained from recent studies, as outlined in this Review article.
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