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Comment
. 2005 Jul 26;102(30):10413-4.
doi: 10.1073/pnas.0504743102. Epub 2005 Jul 18.

Epigenetic drift in aging identical twins

George M Martin  1
Affiliations
Comment

Epigenetic drift in aging identical twins

George M Martin. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Genetically identical animals aged under rigorously controlled environments (in this case, C. elegans worms in spinner cultures) (16) exhibit wide ranges of lifespans. Such survival curves have been observed for inbred and outbred strains of fruit flies, mice, rats, and hamsters, among many other species whose lifespans have been observed under controlled experimental conditions. Such curves are also typical of outbred humans. The data in this figure (and in many other recent studies employing very large numbers of animals) (17) do not fit the classic Gompertz model of a continuous exponential increase in mortality. [Reproduced with permission from ref. (Copyright 1998, The Gerentological Society of America).]
See this image and copyright information in PMC

Comment on

  • Epigenetic differences arise during the lifetime of monozygotic twins.
    Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suñer D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M. Fraga MF, et al. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10604-9. doi: 10.1073/pnas.0500398102. Epub 2005 Jul 11. Proc Natl Acad Sci U S A. 2005. PMID: 16009939 Free PMC article.

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