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Comparative Study
. 1992 Jun;11(6):2103-13.
doi: 10.1002/j.1460-2075.1992.tb05269.x.

Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease

G Bilbe  1 , J Delabie, J Brüggen, H Richener, F A Asselbergs, N Cerletti, C Sorg, K Odink, L Tarcsay, W Wiesendanger, et al.
Affiliations
Comparative Study

Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease

G Bilbe et al. EMBO J. 1992 Jun.

Abstract

We have identified a cDNA coding for a protein of 160 kDa which is expressed in in vitro cultured human peripheral blood monocytes. The predicted amino acid sequence contains an alpha-helical rod domain possessing features characteristic of intermediate filament proteins. However, the immunocytochemical staining pattern, abundance and solubility in Triton X-100/high salt buffers suggest that this protein is probably only associated with the intermediate filament network and represents a new type of intermediate filament associated protein. In a survey of normal, inflammatory and human tumour tissue samples, this protein, which we have named restin, was found to be highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. We suggest that restin overexpression may be a contributing factor in the progression of Hodgkin's disease.

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