Review
doi: 10.1016/j.cell.2005.06.023.
RNAi: the nuts and bolts of the RISC machine
Affiliations
- PMID: 16009129
- DOI: 10.1016/j.cell.2005.06.023
Item in Clipboard
Review
RNAi: the nuts and bolts of the RISC machine
Cell.
.
Free article
Abstract
Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.
Similar articles
-
The Argonautes.Cold Spring Harb Symp Quant Biol. 2006;71:67-72. doi: 10.1101/sqb.2006.71.048. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381282 Review.
-
[RNA binding proteins in the RNA interference phenomenon].Mol Biol (Mosk). 2006 Jul-Aug;40(4):595-608. Mol Biol (Mosk). 2006. PMID: 16913219 Review. Russian.
-
Making RISC.Trends Biochem Sci. 2010 Jul;35(7):368-76. doi: 10.1016/j.tibs.2010.03.009. Epub 2010 Apr 13. Trends Biochem Sci. 2010. PMID: 20395147 Review.
-
Small RNA-mediated gene silencing pathways in C. elegans.Int J Biochem Cell Biol. 2010 Aug;42(8):1306-15. doi: 10.1016/j.biocel.2010.03.006. Epub 2010 Mar 19. Int J Biochem Cell Biol. 2010. PMID: 20227516 Review.
-
microRNA-guided posttranscriptional gene regulation.Biol Chem. 2005 Dec;386(12):1205-18. doi: 10.1515/BC.2005.139. Biol Chem. 2005. PMID: 16336116 Review.
Cited by
-
Robust and efficient COVID-19 detection techniques: A machine learning approach.PLoS One. 2022 Sep 15;17(9):e0274538. doi: 10.1371/journal.pone.0274538. eCollection 2022. PLoS One. 2022. PMID: 36107971 Free PMC article.
-
In Vivo GFP Knockdown by Cationic Nanogel-siRNA Polyplexes.Bioengineering (Basel). 2015 Sep;2(3):160-175. doi: 10.3390/bioengineering2030160. Epub 2015 Jul 22. Bioengineering (Basel). 2015. PMID: 27280121 Free PMC article.
-
The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activities.Nucleic Acids Res. 2015 May 19;43(9):4365-80. doi: 10.1093/nar/gkv328. Epub 2015 Apr 16. Nucleic Acids Res. 2015. PMID: 25883138 Free PMC article. Review.
-
Competing Endogenous RNA Regulations in Neurodegenerative Disorders: Current Challenges and Emerging Insights.Front Mol Neurosci. 2018 Oct 5;11:370. doi: 10.3389/fnmol.2018.00370. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30344479 Free PMC article. Review.
-
Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.J Virol. 2007 May;81(10):5121-31. doi: 10.1128/JVI.01511-06. Epub 2007 Mar 14. J Virol. 2007. PMID: 17360756 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
