Review
doi: 10.1016/j.molmed.2005.06.002.
Linking Kaposi virus to cancer-associated cytokines
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- PMID: 15967719
- DOI: 10.1016/j.molmed.2005.06.002
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Review
Linking Kaposi virus to cancer-associated cytokines
Trends Mol Med.
2005 Jul.
Abstract
Viruses have evolved elaborate strategies to regulate host gene expression, thereby adapting to host stress responses against infection. In a recent report, it was shown that a human oncogenic herpesvirus, Kaposi sarcoma herpesvirus, activates the p38-MK2 pathway to stabilise cytokine transcripts. Specifically, a viral latent protein, kaposin B, binds to and activates MK2, leading to the stabilisation of AU-rich element (ARE)-containing mRNAs, which normally have only a short lifespan. Although the exact mechanism for p38-MK2 activation remains unclear, this study provides a new direction linking viral infection to selective mRNA turnover and cytokine biosynthesis.
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