Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD)
- PMID: 15944407
- DOI: 10.1093/jb/mvi068
Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD)
Abstract
Secreted proteins are synthesized at the endoplasmic reticulum (ER), and a quality control mechanism in the ER is essential to maintain secretory pathway homeostasis. Newly synthesized soluble and integral membrane secreted proteins fold into their native conformations with the aid of ER molecular chaperones before they are transported to post-ER compartments. However, terminally mis-folded proteins may be retained in the ER and degraded by a process called ER-associated degradation (ERAD). Recent studies using yeast have shown that molecular chaperones both in the ER and in the cytosol play key roles during the ERAD of mis-folded proteins. One important role for chaperones during ERAD is to prevent substrate protein aggregation. Substrate selection is another important role for molecular chaperones during ERAD.
Similar articles
-
Mechanism and components of endoplasmic reticulum-associated degradation.J Biochem. 2010 Jan;147(1):19-25. doi: 10.1093/jb/mvp194. Epub 2009 Nov 18. J Biochem. 2010. PMID: 19923195 Review.
-
Reconstitution of endoplasmic reticulum-associated degradation using yeast membranes and cytosol.Methods Mol Biol. 2005;301:175-84. doi: 10.1385/1-59259-895-1:175. Methods Mol Biol. 2005. PMID: 15917632
-
The endoplasmic reticulum-associated degradation and disulfide reductase ERdj5.Methods Enzymol. 2011;490:235-58. doi: 10.1016/B978-0-12-385114-7.00014-3. Methods Enzymol. 2011. PMID: 21266254
-
Protein folding and quality control in the endoplasmic reticulum.Curr Opin Cell Biol. 2004 Aug;16(4):343-9. doi: 10.1016/j.ceb.2004.06.012. Curr Opin Cell Biol. 2004. PMID: 15261665 Review.
-
An in vitro assay for the selective endoplasmic reticulum associated degradation of an unglycosylated secreted protein.Methods. 2005 Apr;35(4):354-9. doi: 10.1016/j.ymeth.2004.10.007. Methods. 2005. PMID: 15804607
Cited by
-
How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.Biochim Biophys Acta. 2013 Nov;1833(11):2447-57. doi: 10.1016/j.bbamcr.2013.03.018. Epub 2013 Apr 2. Biochim Biophys Acta. 2013. PMID: 23557783 Free PMC article. Review.
-
Gene networks governing the response of a calcareous sponge to future ocean conditions reveal lineage-specific XBP1 regulation of the unfolded protein response.Ecol Evol. 2024 Jun 30;14(7):e11652. doi: 10.1002/ece3.11652. eCollection 2024 Jul. Ecol Evol. 2024. PMID: 38952658 Free PMC article.
-
Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger.Appl Microbiol Biotechnol. 2011 Jan;89(2):357-73. doi: 10.1007/s00253-010-2916-5. Epub 2010 Oct 5. Appl Microbiol Biotechnol. 2011. PMID: 20922374 Free PMC article.
-
A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia.Eukaryot Cell. 2009 Nov;8(11):1665-76. doi: 10.1128/EC.00123-09. Epub 2009 Sep 11. Eukaryot Cell. 2009. PMID: 19749174 Free PMC article.
-
The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD).J Biol Chem. 2007 Nov 9;282(45):32665-75. doi: 10.1074/jbc.M705216200. Epub 2007 Sep 6. J Biol Chem. 2007. PMID: 17823116 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
