Comment
doi: 10.1016/j.neuron.2005.05.008.
An unconventional role of neurotransmission in synapse formation
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- PMID: 15944118
- DOI: 10.1016/j.neuron.2005.05.008
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Comment
An unconventional role of neurotransmission in synapse formation
Neuron.
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Free article
Abstract
How do presynaptic inputs regulate synapse formation? In this issue of Neuron, Lin et al. show that the neurotransmitter acetylcholine decreases the stability of AChR clusters. This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction.
Comment on
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Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism.Neuron. 2005 May 19;46(4):569-79. doi: 10.1016/j.neuron.2005.04.002. Neuron. 2005. PMID: 15944126
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