Immunoglobulin gene expression only in the right cells at the right time
- PMID: 1592208
- DOI: 10.1096/fasebj.6.8.1592208
Immunoglobulin gene expression only in the right cells at the right time
Abstract
Study of immunoglobulin gene transcriptional control has disclosed a complexity that rivals that of the antibody repertoire itself. Although some DNA sequences that regulate transcription of these genes were identified almost a decade ago, additional regulatory sequences continue to be discovered, some in regions far removed (as much as 200 kb) from the actual site of transcription. This has invoked models of regulation in which the higher-order structure of chromatin must be taken into account. Within the regulatory DNA sequences themselves, there is a bewildering array of sites that bind proteins and a growing catalog of proteins that can bind each of those sites. The proteins are believed to be the physical link between the regulatory DNA sequences and the protein machinery actually carrying out transcription. Specific interactions among proteins that can bind the same site and among proteins that bind different sites have been described. A challenge remaining is to identify those interactions that occur in vivo and that lead to progressively more efficient Ig production in the developing B cell, but which disallow Ig production in non-B cells.
Similar articles
-
A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.Eur J Biochem. 1990 Feb 14;187(3):507-13. doi: 10.1111/j.1432-1033.1990.tb15332.x. Eur J Biochem. 1990. PMID: 2105887
-
Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.Proc Natl Acad Sci U S A. 1989 Oct;86(19):7341-5. doi: 10.1073/pnas.86.19.7341. Proc Natl Acad Sci U S A. 1989. PMID: 2508087 Free PMC article.
-
HS1,2 enhancer regulation of germline epsilon and gamma2b promoters in murine B lymphocytes: evidence for specific promoter-enhancer interactions.J Immunol. 2001 Sep 15;167(6):3257-65. doi: 10.4049/jimmunol.167.6.3257. J Immunol. 2001. PMID: 11544313
-
Sequences 3' of immunoglobulin heavy chain genes influence their expression.Immunol Rev. 1986 Feb;89:31-48. doi: 10.1111/j.1600-065x.1986.tb01471.x. Immunol Rev. 1986. PMID: 3081431 Review.
-
Regulation of antigen receptor gene assembly in lymphocytes.Immunol Res. 2001;23(2-3):121-33. doi: 10.1385/IR:23:2-3:121. Immunol Res. 2001. PMID: 11444378 Review.
Cited by
-
Selective utilization of basic helix-loop-helix-leucine zipper proteins at the immunoglobulin heavy-chain enhancer.Mol Cell Biol. 1997 Jan;17(1):18-23. doi: 10.1128/MCB.17.1.18. Mol Cell Biol. 1997. PMID: 8972181 Free PMC article.
-
Reporter genes in transgenic mice.Transgenic Res. 1994 May;3(3):182-94. doi: 10.1007/BF01973986. Transgenic Res. 1994. PMID: 8025596 Review.
-
The E47 transcription factor binds to the enhancer sequences of recombinant murine leukemia viruses and influences enhancer function.J Virol. 1995 Jul;69(7):4142-8. doi: 10.1128/JVI.69.7.4142-4148.1995. J Virol. 1995. PMID: 7769673 Free PMC article.
-
Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.J Immunol. 2010 Nov 15;185(10):6049-57. doi: 10.4049/jimmunol.0902992. Epub 2010 Oct 11. J Immunol. 2010. PMID: 20937850 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
