doi: 10.1126/science.1114519.
Epub 2005 May 26.
MicroRNA expression in zebrafish embryonic development
Affiliations
- PMID: 15919954
- DOI: 10.1126/science.1114519
Item in Clipboard
MicroRNA expression in zebrafish embryonic development
Science.
.
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play essential roles in embryonic development. We determined the temporal and spatial expression patterns of 115 conserved vertebrate miRNAs in zebrafish embryos by microarrays and by in situ hybridizations, using locked-nucleic acid-modified oligonucleotide probes. Most miRNAs were expressed in a highly tissue-specific manner during segmentation and later stages, but not early in development, which suggests that their role is not in tissue fate establishment but in differentiation or maintenance of tissue identity.
Similar articles
-
Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes.J Exp Biol. 2009 Jun;212(Pt 12):1781-93. doi: 10.1242/jeb.029918. J Exp Biol. 2009. PMID: 19482995
-
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes.Nat Methods. 2006 Jan;3(1):27-9. doi: 10.1038/nmeth843. Nat Methods. 2006. PMID: 16369549
-
MicroRNA function and mechanism: insights from zebra fish.Cold Spring Harb Symp Quant Biol. 2006;71:195-203. doi: 10.1101/sqb.2006.71.055. Cold Spring Harb Symp Quant Biol. 2006. PMID: 17381297 Review.
-
Genomic organization and embryonic expression of miR-430 in medaka (Oryzias latipes): insights into the post-transcriptional gene regulation in early development.Gene. 2010 Jan 1;449(1-2):41-9. doi: 10.1016/j.gene.2009.09.005. Epub 2009 Sep 19. Gene. 2010. PMID: 19770025
-
Camels and zebrafish, viruses and cancer: a microRNA update.Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R183-90. doi: 10.1093/hmg/ddi271. Hum Mol Genet. 2005. PMID: 16244316 Review.
Cited by
-
PCR-Free, Multiplexed Expression Profiling of microRNAs Using Silicon Photonic Microring Resonators.Anal Chem. 2016 Nov 1;88(21):10347-10351. doi: 10.1021/acs.analchem.6b03350. Epub 2016 Oct 19. Anal Chem. 2016. PMID: 27726377 Free PMC article.
-
MicroRNA 218 mediates the effects of Tbx5a over-expression on zebrafish heart development.PLoS One. 2012;7(11):e50536. doi: 10.1371/journal.pone.0050536. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226307 Free PMC article.
-
miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish.Development. 2012 Dec 1;139(23):4356-64. doi: 10.1242/dev.083774. Development. 2012. PMID: 23132244 Free PMC article.
-
miR-9*- and miR-124a-Mediated switching of chromatin remodelling complexes is altered in rat spina bifida aperta.Neurochem Res. 2013 Aug;38(8):1605-15. doi: 10.1007/s11064-013-1062-8. Epub 2013 May 16. Neurochem Res. 2013. PMID: 23677776
-
Transcriptome-wide analysis of small RNA expression in early zebrafish development.RNA. 2012 May;18(5):915-29. doi: 10.1261/rna.029090.111. Epub 2012 Mar 8. RNA. 2012. PMID: 22408181 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
