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Review
. 2005 Oct;89(2):124-52.
doi: 10.1016/j.pbiomolbio.2004.09.003.

Automation of macromolecular crystallography beamlines

Steffi Arzt  1 , Antonia Beteva, Florent Cipriani, Solange Delageniere, Franck Felisaz, Gabriele Förstner, Elspeth Gordon, Ludovic Launer, Bernard Lavault, Gordon Leonard, Trevor Mairs, Andrew McCarthy, Joanne McCarthy, Sean McSweeney, Jens Meyer, Edward Mitchell, Stephanie Monaco, Didier Nurizzo, Raimond Ravelli, Vicente Rey, William Shepard, Darren Spruce, Olof Svensson, Pascal Theveneau
Affiliations
Free article
Review

Automation of macromolecular crystallography beamlines

Steffi Arzt et al. Prog Biophys Mol Biol. 2005 Oct.
Free article

Abstract

The production of three-dimensional crystallographic structural information of macromolecules can now be thought of as a pipeline which is being streamlined at every stage from protein cloning, expression and purification, through crystallisation to data collection and structure solution. Synchrotron X-ray beamlines are a key section of this pipeline as it is at these that the X-ray diffraction data that ultimately leads to the elucidation of macromolecular structures are collected. The burgeoning number of macromolecular crystallography (MX) beamlines available worldwide may be enhanced significantly with the automation of both their operation and of the experiments carried out on them. This paper reviews the current situation and provides a glimpse of how a MX beamline may look in the not too distant future.

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