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Review
. 2005 Apr:1040:337-9.
doi: 10.1196/annals.1327.055.

Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH

Tatjana Haitina  1 , Janis Klovins, Helgi B Schiöth
Affiliations
Review

Pharmacological characterization of melanocortin receptors in fish suggests an important role for ACTH

Tatjana Haitina et al. Ann N Y Acad Sci. 2005 Apr.

Abstract

The melanocortin (MC) receptor subtypes have distinctive characteristic binding profiles. We found that the trout and Fugu MC4 receptors have similar affinity for alpha-MSH and beta-MSH and a much higher affinity for ACTH than does the human MC4 receptor. The Fugu MC1 and the trout and Fugu MC5 receptors also have higher affinity for ACTH-derived peptides than alpha-, beta-, or gamma-MSH. It is tempting to speculate that ACTH-derived peptides may have played an important role as "original" ligands at the MC receptors, while the specificity of the different subtypes for the alpha-, beta-, and gamma-MSH peptides may have appeared at later stages during vertebrate evolution.

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