Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties
- PMID: 15879007
- DOI: 10.1124/jpet.105.085431
Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties
Abstract
Cyclooxygenase (COX)-3, a novel COX splice variant, was suggested as the key to unlocking the mystery of the mechanism of action of acetaminophen. Although COX-3 might have COX activity in canines, and this activity might be inhibited by acetaminophen, its low expression level and the kinetics indicate unlikely clinical relevance. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity; therefore, it is improbable that COX-3 in these species plays a role in prostaglandin-mediated fever and pain. The aim of this review is to evaluate the literature that seeks to point out critical theoretical and methodological limitations of the COX-3 studies that led several investigators to scientifically questionable conclusions.
Comment in
-
Comments on "acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties".J Pharmacol Exp Ther. 2005 Dec;315(3):1412-4; author reply 1415-6. doi: 10.1124/jpet.105.094169. J Pharmacol Exp Ther. 2005. PMID: 16291877 No abstract available.
-
Further benefits of cyanoacrylate glue for central venous catheterisation.Anaesthesia. 2015 Jun;70(6):758. doi: 10.1111/anae.13105. Anaesthesia. 2015. PMID: 25959189 No abstract available.
Similar articles
-
Comments on "acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties".J Pharmacol Exp Ther. 2005 Dec;315(3):1412-4; author reply 1415-6. doi: 10.1124/jpet.105.094169. J Pharmacol Exp Ther. 2005. PMID: 16291877 No abstract available.
-
COX-3 and the mechanism of action of paracetamol/acetaminophen.Prostaglandins Leukot Essent Fatty Acids. 2005 Feb;72(2):85-7. doi: 10.1016/j.plefa.2004.10.005. Prostaglandins Leukot Essent Fatty Acids. 2005. PMID: 15626590 Review.
-
Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11165-9. doi: 10.1073/pnas.0404185101. Epub 2004 Jul 19. Proc Natl Acad Sci U S A. 2004. PMID: 15263079 Free PMC article.
-
Human cyclooxygenase-1b is not the elusive target of acetaminophen.Eur J Pharmacol. 2006 Dec 3;551(1-3):50-3. doi: 10.1016/j.ejphar.2006.08.079. Epub 2006 Sep 12. Eur J Pharmacol. 2006. PMID: 17045584
-
Mechanism of action of acetaminophen: is there a cyclooxygenase 3?Clin Infect Dis. 2000 Oct;31 Suppl 5:S202-10. doi: 10.1086/317520. Clin Infect Dis. 2000. PMID: 11113024 Review.
Cited by
-
The role of aspirin in cancer prevention.Nat Rev Clin Oncol. 2012 Apr 3;9(5):259-67. doi: 10.1038/nrclinonc.2011.199. Nat Rev Clin Oncol. 2012. PMID: 22473097 Review.
-
The Role of Eicosanoids in Alzheimer's Disease.Int J Environ Res Public Health. 2019 Jul 18;16(14):2560. doi: 10.3390/ijerph16142560. Int J Environ Res Public Health. 2019. PMID: 31323750 Free PMC article. Review.
-
Prostaglandins in bone: bad cop, good cop?Trends Endocrinol Metab. 2010 May;21(5):294-301. doi: 10.1016/j.tem.2009.12.004. Epub 2010 Jan 14. Trends Endocrinol Metab. 2010. PMID: 20079660 Free PMC article. Review.
-
Regular adult aspirin use decreases the risk of non-small cell lung cancer among women.Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):148-57. doi: 10.1158/1055-9965.EPI-07-0517. Epub 2008 Jan 9. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18187393 Free PMC article.
-
Licofelone: the answer to unmet needs in osteoarthritis therapy?Curr Rheumatol Rep. 2008 Jan;10(1):43-8. doi: 10.1007/s11926-008-0008-7. Curr Rheumatol Rep. 2008. PMID: 18457611 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
