Review
doi: 10.1038/nrm1644.
MicroRNA biogenesis: coordinated cropping and dicing
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- PMID: 15852042
- DOI: 10.1038/nrm1644
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Review
MicroRNA biogenesis: coordinated cropping and dicing
Nat Rev Mol Cell Biol.
2005 May.
Abstract
The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.
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