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. 2005 Apr;22(4):507-17.
doi: 10.1016/j.immuni.2005.03.004.

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

Neil C Rogers  1 , Emma C Slack, Alexander D Edwards, Martijn A Nolte, Oliver Schulz, Edina Schweighoffer, David L Williams, Siamon Gordon, Victor L Tybulewicz, Gordon D Brown, Caetano Reis e Sousa
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Free article

Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins

Neil C Rogers et al. Immunity. 2005 Apr.
Free article

Erratum in

  • Immunity. 2005 Jun;22(6):773-4

Abstract

Pattern-recognition receptors (PRRs) detect molecular signatures of microbes and initiate immune responses to infection. Prototypical PRRs such as Toll-like receptors (TLRs) signal via a conserved pathway to induce innate response genes. In contrast, the signaling pathways engaged by other classes of putative PRRs remain ill defined. Here, we demonstrate that the beta-glucan receptor Dectin-1, a yeast binding C type lectin known to synergize with TLR2 to induce TNF alpha and IL-12, can also promote synthesis of IL-2 and IL-10 through phosphorylation of the membrane proximal tyrosine in the cytoplasmic domain and recruitment of Syk kinase. syk-/- dendritic cells (DCs) do not make IL-10 or IL-2 upon yeast stimulation but produce IL-12, indicating that the Dectin-1/Syk and Dectin-1/TLR2 pathways can operate independently. These results identify a novel signaling pathway involved in pattern recognition by C type lectins and suggest a potential role for Syk kinase in regulation of innate immunity.

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