Antiviral therapy of influenza
- PMID: 15833061
- DOI: 10.1517/13543784.14.3.305
Antiviral therapy of influenza
Abstract
Influenza viruses are a leading cause of morbidity and mortality worldwide despite the availability of an effective vaccine. The emergence of highly pathogenic avian influenza viruses in southeast Asia, which can infect and kill humans and for which there is no vaccine, has heightened the need to establish a supply of effective antivirals. Two effective classes of anti-influenza drugs are currently available, and many attractive targets exist for further development. This review presents the current status of antiviral therapy of, and highlights the challenges presented by, the threat of pandemic influenza.
Similar articles
-
Novel strategies for prevention and treatment of influenza.Expert Opin Ther Targets. 2005 Feb;9(1):1-22. doi: 10.1517/14728222.9.1.1. Expert Opin Ther Targets. 2005. PMID: 15757479 Review.
-
Antiviral resistance and the control of pandemic influenza.PLoS Med. 2007 Jan;4(1):e15. doi: 10.1371/journal.pmed.0040015. PLoS Med. 2007. PMID: 17253900 Free PMC article.
-
Planning for the next pandemic of influenza.Rev Med Virol. 2001 Jan-Feb;11(1):59-70. doi: 10.1002/rmv.301. Rev Med Virol. 2001. PMID: 11241802 Review.
-
Pandemic influenza: overview of vaccines and antiviral drugs.Yale J Biol Med. 2005 Oct;78(5):321-8. Yale J Biol Med. 2005. PMID: 17132338 Free PMC article. Review.
-
Assessing the role of basic control measures, antivirals and vaccine in curtailing pandemic influenza: scenarios for the US, UK and the Netherlands.J R Soc Interface. 2007 Jun 22;4(14):505-21. doi: 10.1098/rsif.2006.0186. J R Soc Interface. 2007. PMID: 17251132 Free PMC article.
Cited by
-
Unsaturated N-acetyl- D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase.Glycoconj J. 2006 Feb;23(1-2):127-33. doi: 10.1007/s10719-006-5445-9. Glycoconj J. 2006. PMID: 16575530
-
Preparing for the next influenza pandemic.Pediatr Infect Dis J. 2008 Oct;27(10 Suppl):S57-9. doi: 10.1097/INF.0b013e3181684d41. Pediatr Infect Dis J. 2008. PMID: 18820579 Free PMC article.
-
Preventing and treating secondary bacterial infections with antiviral agents.Antivir Ther. 2011;16(2):123-35. doi: 10.3851/IMP1730. Antivir Ther. 2011. PMID: 21447860 Free PMC article. Review.
-
Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.ACS Med Chem Lett. 2019 Nov 25;10(12):1667-1673. doi: 10.1021/acsmedchemlett.9b00447. eCollection 2019 Dec 12. ACS Med Chem Lett. 2019. PMID: 31857844 Free PMC article.
-
Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses.J Virol. 2015 Sep;89(17):9010-20. doi: 10.1128/JVI.00583-15. Epub 2015 Jun 17. J Virol. 2015. PMID: 26085167 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical