The genetic basis of Ro and La antibody formation in systemic lupus erythematosus. Results of a multicenter study. The SLE Study Group
- PMID: 1579805
- DOI: 10.1007/BF00301501
The genetic basis of Ro and La antibody formation in systemic lupus erythematosus. Results of a multicenter study. The SLE Study Group
Abstract
Antibodies against Ro and La, including recombinant La and recombinant 60 kD-Ro, were determined by counter immunoelectrophoresis and ELISA in over 300 central European systemic lupus erythematosus (SLE) patients. The presence of both Ro and La antibodies was strongly associated with the MHC haplotype B8-C4AQ0-DR3-DQ2, the association being strongest for DR3. After exclusion of all B8-DR3 positive patients only DR3 positive patients still showed an increased incidence of Ro and La antibodies, suggesting DR3 as the primary association factor. High titers of La antibody, but not of 60 kD-Ro antibody, were also significantly associated with the presence of DR3. Other DR and DQ antigens or heterozygous DQ combinations were not significantly associated with Ro and La antibodies.
Similar articles
-
MHC associations of autoantibodies against recombinant Ro and La proteins in systemic lupus erythematosus. Results of a multicenter study. SLE Study Group.Rheumatol Int. 1992;12(5):169-73. doi: 10.1007/BF00302148. Rheumatol Int. 1992. PMID: 1290018
-
No direct correlation between HLA-DPB1 and antibodies against recombinant Ro (SS-A)/La (SS-B) proteins in systemic lupus erythematosus. SLE Study Group.Rheumatol Int. 1993;13(4):155-8. doi: 10.1007/BF00301263. Rheumatol Int. 1993. PMID: 8310208
-
Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.West Indian Med J. 2007 Mar;56(2):130-3. doi: 10.1590/s0043-31442007000200005. West Indian Med J. 2007. PMID: 17910142
-
Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus.Autoimmun Rev. 2017 Feb;16(2):132-135. doi: 10.1016/j.autrev.2016.12.004. Epub 2016 Dec 14. Autoimmun Rev. 2017. PMID: 27988434 Review.
-
Anti-La antibodies.Rheum Dis Clin North Am. 1992 May;18(2):359-76. Rheum Dis Clin North Am. 1992. PMID: 1626074 Review.
Cited by
-
Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren's syndrome.Korean J Intern Med. 1997 Jun;12(2):176-81. doi: 10.3904/kjim.1997.12.2.176. Korean J Intern Med. 1997. PMID: 9439152 Free PMC article.
-
HLA class II genes and antibodies against recombinant U1-nRNP proteins in patients with systemic lupus erythematosus. SLE Study Group.Rheumatol Int. 1994;14(2):63-9. doi: 10.1007/BF00300249. Rheumatol Int. 1994. PMID: 7824837
-
Increased alloreactive and autoreactive antihuman leucocyte antigen antibodies associated with systemic lupus erythematosus and rheumatoid arthritis.Lupus Sci Med. 2018 Sep 25;5(1):e000278. doi: 10.1136/lupus-2018-000278. eCollection 2018. Lupus Sci Med. 2018. PMID: 30305912 Free PMC article.
-
HLA antigens in Malay patients with systemic lupus erythematosus: association with clinical and autoantibody expression.Korean J Intern Med. 2001 Jun;16(2):123-31. doi: 10.3904/kjim.2001.16.2.123. Korean J Intern Med. 2001. PMID: 11590899 Free PMC article. Clinical Trial.
-
Systemic lupus erythematosus diagnostics in the 'omics' era.Int J Clin Rheumtol. 2013 Dec 1;8(6):671-687. doi: 10.2217/ijr.13.59. Int J Clin Rheumtol. 2013. PMID: 24860621 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Research Materials