Preventing frail health
- PMID: 1576567
Preventing frail health
Abstract
Frailty is a state of reduced physiologic reserve associated with increased susceptibility to disability. Reduced physiologic capacity in neurologic control, mechanical performance, and energy metabolism are the major components of frailty. Although disease is an important cause of frailty, there is sufficient epidemiologic and experimental evidence to conclude that frailty is also due to the additive effects of low-grade physiologic loss resulting from a sedentary lifestyle and more rapid loss due to acute insults (illness, injuries, major life events) that result in periods of limited activity and bedrest. The pathogenesis of frailty involves a complicated interaction of factors that block recovery from rapid physiologic loss. To some extent, frailty is preventable. Approaches to prevention include (1) the periodic monitoring of key physiologic indicators of frailty, (2) the prevention of physiologic loss and acute and subacute episodes of physiologic loss, (3) the prediction of episodes of physiologic loss and the reduction of frailty prior to the loss, and (4) the removal of obstacles to recovery once physiologic loss has occurred.
Similar articles
-
Frailty, inflammation, and cardiovascular disease: evidence of a connection.Am J Geriatr Cardiol. 2008 Mar-Apr;17(2):101-7. Am J Geriatr Cardiol. 2008. PMID: 18326951 Review.
-
Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I.Am J Epidemiol. 2008 Jan 15;167(2):240-8. doi: 10.1093/aje/kwm270. Epub 2007 Sep 28. Am J Epidemiol. 2008. PMID: 17906296
-
Sarcopenia: a major modifiable cause of frailty in the elderly.J Nutr Health Aging. 2000;4(3):140-2. J Nutr Health Aging. 2000. PMID: 10936900 Review.
-
Frailty in the elderly: the physical dimension.Eura Medicophys. 2007 Sep;43(3):407-15. Epub 2006 Nov 22. Eura Medicophys. 2007. PMID: 17117147 Review.
-
Aging, disability and frailty.Ann Nutr Metab. 2008;52 Suppl 1:6-11. doi: 10.1159/000115340. Epub 2008 Mar 7. Ann Nutr Metab. 2008. PMID: 18382070 Review.
Cited by
-
Barriers and facilitators to the implementation of prehabilitation for elderly frail patients prior to elective surgery: a qualitative study with healthcare professionals.BMC Health Serv Res. 2024 Apr 26;24(1):536. doi: 10.1186/s12913-024-10993-2. BMC Health Serv Res. 2024. PMID: 38671446 Free PMC article.
-
Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial.J Cancer Surviv. 2024 Aug;18(4):1179-1189. doi: 10.1007/s11764-024-01592-5. Epub 2024 Apr 20. J Cancer Surviv. 2024. PMID: 38642204 Clinical Trial.
-
To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.J Clin Med. 2024 Jan 26;13(3):721. doi: 10.3390/jcm13030721. J Clin Med. 2024. PMID: 38337415 Free PMC article. Review.
-
Association of frailty with mortality in cancer survivors: results from NHANES 1999-2018.Sci Rep. 2024 Jan 18;14(1):1619. doi: 10.1038/s41598-023-50019-1. Sci Rep. 2024. PMID: 38238362 Free PMC article.
-
Preoperative Frailty Assessed Comprehensively by a Questionnaire Predicts a Poor Survival Following Curative Resection of Gastric Cancer.Cancer Diagn Progn. 2023 Nov 3;3(6):687-694. doi: 10.21873/cdp.10273. eCollection 2023 Nov-Dec. Cancer Diagn Progn. 2023. PMID: 37927806 Free PMC article.