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Review
. 1992 Jan;74(1):5-11.
doi: 10.1016/0300-9084(92)90179-i.

Mammalian beta-D-mannosidase and beta-mannosidosis

F Percheron  1 , M J Foglietti, M Bernard, B Ricard
Affiliations
Review

Mammalian beta-D-mannosidase and beta-mannosidosis

F Percheron et al. Biochimie. 1992 Jan.

Abstract

Lysosomal beta-D-mannosidase is the last exoglycosidase involved in the sequential degradation of the N-glycosylproteins glycans. Research on this enzyme was restricted before the discovery of its hereditary deficiency, first in goat (1981) and later in man (1986). We describe the biochemical aspects of these beta-mannosidosis and the properties of the beta-mannosidases of mammalian origin. Our own results concerning human enzyme (from kidney and urine, seminal plasma and blood cells) suggest that, apart from the case of the inherited disease, beta-mannosidase may become a useful tool in other pathologies.

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