Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Apr 15;283 ( Pt 2)(Pt 2):403-8.
doi: 10.1042/bj2830403.

Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells

Affiliations

Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells

D J Grainger et al. Biochem J. .

Abstract

Hexamethylenebisacetamide (HMBA) selectively and reversibly inhibited proliferation of human and rat vascular smooth-muscle cells (VSMCs) compared with endothelial cells, fibroblasts or lymphocytes. Half-maximal inhibition of VSMC proliferation occurred at 2-5 mM-HMBA, and at 30- greater than 50 mM for other cell types. HMBA also prevented de-differentiation, defined by the loss of smooth-muscle-specific myosin heavy chain, of primary rat VSMCs and caused partial re-differentiation of subcultured cells. Other inhibitors of ADP-ribosyltransferase were also selective inhibitors of VSMC proliferation.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Biol Rev Camb Philos Soc. 1990 Nov;65(4):623-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6 - PubMed
    1. Biochem J. 1991 Jul 1;277 ( Pt 1):145-51 - PubMed
    1. Biochem Biophys Res Commun. 1991 May 15;176(3):1365-70 - PubMed
    1. Cancer Res. 1987 Feb 1;47(3):659-66 - PubMed

Publication types