Review
doi: 10.1016/j.cell.2005.02.002.
The plasticity of aging: insights from long-lived mutants
Affiliations
- PMID: 15734678
- DOI: 10.1016/j.cell.2005.02.002
Item in Clipboard
Review
The plasticity of aging: insights from long-lived mutants
Cell.
.
Free article
Abstract
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. These mutations have revealed evolutionarily conserved pathways for aging, some of which appear to extend life span in response to sensory cues, caloric restriction, or stress. Many mutations affecting longevity pathways delay age-related disease, and the molecular analysis of these pathways is leading to a mechanistic understanding of how these two processes--aging and disease susceptibility--are linked.
Similar articles
-
Sex and death: what is the connection?Cell. 2005 Feb 25;120(4):461-72. doi: 10.1016/j.cell.2005.01.026. Cell. 2005. PMID: 15734679 Review.
-
The genetics of human longevity.Am J Med. 2004 Dec 1;117(11):851-60. doi: 10.1016/j.amjmed.2004.06.033. Am J Med. 2004. PMID: 15589490 Review.
-
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis).Exp Gerontol. 2010 Jun;45(6):410-8. doi: 10.1016/j.exger.2010.03.014. Epub 2010 Mar 27. Exp Gerontol. 2010. PMID: 20350594 Review.
-
Stress resistance in long-lived mouse models.Exp Gerontol. 2006 Oct;41(10):1014-9. doi: 10.1016/j.exger.2006.06.061. Epub 2006 Sep 7. Exp Gerontol. 2006. PMID: 16962277 Review.
-
Reduced insulin/IGF-1 signalling and human longevity.Aging Cell. 2005 Apr;4(2):79-85. doi: 10.1111/j.1474-9728.2005.00148.x. Aging Cell. 2005. PMID: 15771611
Cited by
-
Uncovering the Molecular Pathways Implicated in the Anti-Cancer Activity of the Imidazoquinoxaline Derivative EAPB02303 Using a Caenorhabditis elegans Model.Int J Mol Sci. 2024 Jul 16;25(14):7785. doi: 10.3390/ijms25147785. Int J Mol Sci. 2024. PMID: 39063027 Free PMC article.
-
Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of Caenorhabditis elegans.MicroPubl Biol. 2024 Apr 10;2024:10.17912/micropub.biology.001090. doi: 10.17912/micropub.biology.001090. eCollection 2024. MicroPubl Biol. 2024. PMID: 38660564 Free PMC article.
-
Exploring juventology: unlocking the secrets of youthspan and longevity programs.Front Aging. 2024 Apr 4;5:1379289. doi: 10.3389/fragi.2024.1379289. eCollection 2024. Front Aging. 2024. PMID: 38638872 Free PMC article. Review.
-
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans.Geroscience. 2024 Apr 8. doi: 10.1007/s11357-024-01147-7. Online ahead of print. Geroscience. 2024. PMID: 38589671
-
Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.Nat Commun. 2024 Feb 26;15(1):1718. doi: 10.1038/s41467-024-45984-8. Nat Commun. 2024. PMID: 38409097 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
