Review
doi: 10.1038/nrg1521.
Genome-wide association studies for common diseases and complex traits
Affiliations
- PMID: 15716906
- DOI: 10.1038/nrg1521
Item in Clipboard
Review
Genome-wide association studies for common diseases and complex traits
Nat Rev Genet.
2005 Feb.
Abstract
Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.
Similar articles
-
Finding genes that underlie complex traits.Science. 2002 Dec 20;298(5602):2345-9. doi: 10.1126/science.1076641. Science. 2002. PMID: 12493905 Review.
-
What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?J Intern Med. 2008 Jan;263(1):16-27. doi: 10.1111/j.1365-2796.2007.01895.x. J Intern Med. 2008. PMID: 18088250 Review.
-
Genome-wide association studies for complex traits: consensus, uncertainty and challenges.Nat Rev Genet. 2008 May;9(5):356-69. doi: 10.1038/nrg2344. Nat Rev Genet. 2008. PMID: 18398418 Review.
-
Statistical multilocus methods for disequilibrium analysis in complex traits.Hum Mutat. 2001 Apr;17(4):285-8. doi: 10.1002/humu.25. Hum Mutat. 2001. PMID: 11295826
-
Genetic association studies of complex traits: design and analysis issues.Mutat Res. 2005 Jun 3;573(1-2):54-69. doi: 10.1016/j.mrfmmm.2005.01.006. Mutat Res. 2005. PMID: 15829237 Review.
Cited by
-
Locus heterogeneity disease genes encode proteins with high interconnectivity in the human protein interaction network.Front Genet. 2014 Dec 9;5:434. doi: 10.3389/fgene.2014.00434. eCollection 2014. Front Genet. 2014. PMID: 25538735 Free PMC article.
-
Genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits.PLoS One. 2012;7(2):e30910. doi: 10.1371/journal.pone.0030910. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359555 Free PMC article.
-
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.PLoS Genet. 2013 Apr;9(4):e1003455. doi: 10.1371/journal.pgen.1003455. Epub 2013 Apr 25. PLoS Genet. 2013. PMID: 23637625 Free PMC article.
-
An ICA with reference approach in identification of genetic variation and associated brain networks.Front Hum Neurosci. 2012 Feb 22;6:21. doi: 10.3389/fnhum.2012.00021. eCollection 2012. Front Hum Neurosci. 2012. PMID: 22371699 Free PMC article.
-
Genome-wide association analysis on five isolated populations identifies variants of the HLA-DOA gene associated with white wine liking.Eur J Hum Genet. 2015 Dec;23(12):1717-22. doi: 10.1038/ejhg.2015.34. Epub 2015 Mar 11. Eur J Hum Genet. 2015. PMID: 25758996 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
