Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
- PMID: 15716562
- DOI: 10.1056/NEJMoa044307
Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
Abstract
In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. The cerebrospinal fluid contained 1 white cell per cubic millimeter, normal glucose levels, and increased levels of protein (0.81 g per liter). The diagnosis of avian influenza A (H5N1) was established by isolation of the virus from cerebrospinal fluid, fecal, throat, and serum specimens. The patient's nine-year-old sister had died from a similar syndrome two weeks earlier. In both siblings, the clinical diagnosis was acute encephalitis. Neither patient had respiratory symptoms at presentation. These cases suggest that the spectrum of influenza H5N1 is wider than previously thought.
Copyright 2005 Massachusetts Medical Society.
Comment in
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Diarrhoea as a presentation of bird flu infection: a summary on its correlation to outcome in Thai cases.Gut. 2005 Oct;54(10):1506. doi: 10.1136/gut.2005.072488. Gut. 2005. PMID: 16162964 Free PMC article. Review. No abstract available.
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