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. 2005 Jan;28(1):47-51.
doi: 10.1002/clc.4960280112.

Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication

Young-Cheoul Doo  1 , Sang-Jin Han, Woo-Jung Park, Seong-Man Kim, Seung-Hyuk Choi, Goo-Yeong Cho, Kyung-Soon Hong, Kyoo-Rok Han, Nam-Ho Lee, Dong-Jin Oh, Kyu-Hyung Ryu, Chong-Yun Rhim, Kwang-Hwahk Lee, Yung Lee
Affiliations

Associations between C-reactive protein and circulating cell adhesion molecules in patients with unstable angina undergoing coronary intervention and their clinical implication

Young-Cheoul Doo et al. Clin Cardiol. 2005 Jan.

Abstract

Background: There is growing evidence that C-reactive protein (CRP) may have a direct role in the pathogenesis of atherosclerosis.

Hypothesis: The purpose of this study was to assess associations between CRP and adhesion molecules and to determine the prognostic value of adhesion molecules as a predictor of cardiac events in patients with unstable angina.

Methods: Fifty-five consecutive patients (33 males, mean age 61 years) with unstable angina (Braunwald class IIb or IIIb) undergoing coronary stenting were included in this study.

Results: The test for a trend toward increasing intercellular adhesion molecule (ICAM)-1 concentrations by the 75th percentile of CRP levels at 72 h after coronary stenting was significant (p = 0.03). At 72 h after coronary stenting, CRP levels were the only determinants of ICAM-1 concentrations by multiple linear regression analysis. An elevated level of CRP (>5.4 mg/l) (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.3-3.7, p < 0.05) and ICAM-1 (>321 ng/ml) (OR 1.2, 95% CI 1.1-2.1, p < 0.05) at 72 h after coronary stenting is an independent risk factor for an adverse cardiac event.

Conclusions: These results suggest that in patients with unstable angina undergoing coronary stenting, the measurements of inflammatory parameters, especially CRP and ICAM-1, may be useful for identifying those at higher risk of a cardiac event, and CRP may play a direct role in promoting the inflammatory component of atherosclerosis by inducing significant expression of ICAM-1.

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References

    1. Ross R: Atherosclerosis—an inflammatory disease. N Engl J Med 1999; 340: 115–126 - PubMed
    1. Havekate F, Thompson SG, Pyke SD, Gallimore JR, for the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group : Production of C‐reactive protein and risk of coronary events in stable and unstable angina. Lancet 1997; 349: 462–466 - PubMed
    1. Cybulsky MI, Gimbrone MA: Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 1991; 251: 788–790 - PubMed
    1. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P: An atherogenic diet rapidly induces VCAM‐1, a cytokine‐regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb Vasc Biol 1993; 13: 197–204 - PubMed
    1. Sakai A, Kume N, Nishi E, Tanoue K, Miyasaka M, Kita T: P‐selectin and vascular cell adhesion molecule‐1 are focally expressed in aortas of hyper‐cholesterolemic rabbits before intimal accumulation of macrophages and T‐lymphocytes. Arterioscler Thromb Vasc Biol 1997; 17: 310–316 - PubMed

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