Review
doi: 10.4161/cc.4.3.1519.
Epub 2005 Mar 7.
c-Met signalling: spatio-temporal decisions
Affiliations
- PMID: 15701970
- DOI: 10.4161/cc.4.3.1519
Item in Clipboard
Review
c-Met signalling: spatio-temporal decisions
Cell Cycle.
2005 Mar.
Abstract
The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth factor/receptor HGF/c-Met, demonstrates that the PKC-regulated location of downstream transducers, specifically the MAPkinase ERK1/2, has a profound positive influence on cell migration, despite apparently reducing the steady state level of ERK1/2 activation. The mechanisms involved and the implications for signalling studies are discussed.
Similar articles
-
Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells.Invest Ophthalmol Vis Sci. 2008 Feb;49(2):497-504. doi: 10.1167/iovs.07-0975. Invest Ophthalmol Vis Sci. 2008. PMID: 18234991
-
PKC controls HGF-dependent c-Met traffic, signalling and cell migration.EMBO J. 2004 Oct 1;23(19):3721-34. doi: 10.1038/sj.emboj.7600396. Epub 2004 Sep 23. EMBO J. 2004. PMID: 15385963 Free PMC article.
-
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.J Cell Biol. 2008 Sep 8;182(5):855-63. doi: 10.1083/jcb.200806076. J Cell Biol. 2008. PMID: 18779368 Free PMC article.
-
Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes.Biochem Cell Biol. 2004 Dec;82(6):603-9. doi: 10.1139/o04-110. Biochem Cell Biol. 2004. PMID: 15674427 Review.
-
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling.Biochem Pharmacol. 2002 Sep;64(5-6):755-63. doi: 10.1016/s0006-2952(02)01135-8. Biochem Pharmacol. 2002. PMID: 12213567 Review.
Cited by
-
The PSI Domain of the MET Oncogene Encodes a Functional Disulfide Isomerase Essential for the Maturation of the Receptor Precursor.Int J Mol Sci. 2022 Oct 17;23(20):12427. doi: 10.3390/ijms232012427. Int J Mol Sci. 2022. PMID: 36293286 Free PMC article.
-
Rab GTPase regulation of VEGFR2 trafficking and signaling in endothelial cells.Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1119-24. doi: 10.1161/ATVBAHA.109.186239. Epub 2009 Apr 16. Arterioscler Thromb Vasc Biol. 2009. PMID: 19372461 Free PMC article.
-
Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway.Cell Signal. 2008 May;20(5):825-35. doi: 10.1016/j.cellsig.2007.12.013. Epub 2007 Dec 27. Cell Signal. 2008. PMID: 18262389 Free PMC article.
-
The Therapeutic Targeting of HGF/c-Met Signaling in Hepatocellular Carcinoma: Alternative Approaches.Cancers (Basel). 2017 May 26;9(6):58. doi: 10.3390/cancers9060058. Cancers (Basel). 2017. PMID: 28587113 Free PMC article. Review.
-
Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.PLoS One. 2013 Apr 23;8(4):e62357. doi: 10.1371/journal.pone.0062357. Print 2013. PLoS One. 2013. PMID: 23626807 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
