Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Nov;30(4):697-703.
doi: 10.1081/erc-200043979.

SR-BI and HDL cholesteryl ester metabolism

Margery A Connelly  1 , David L Williams
Affiliations
Review

SR-BI and HDL cholesteryl ester metabolism

Margery A Connelly et al. Endocr Res. 2004 Nov.

Abstract

Scavenger receptor class B, type I (SR-BI) is the receptor for high density lipoprotein (HDL) that mediates cellular uptake of HDL cholesteryl ester (CE) and is a major route for cholesterol delivery to steroidogenic pathways. SR-BI is localized in specialized microvillar channel plasma membrane compartments that retain HDL and are sites for HDL CE selective uptake. In fact, adrenal gland microvillar channel formation is regulated by adrenocorticotropin hormone and requires SR-BI expression. SR-BI-mediated uptake of HDL CE is a two-step process requiring high affinity HDL binding followed by transfer of CE to the membrane. SR-BI delivers HDL CE to sites in the membrane where it is readily metabolized to free cholesterol by cell type-specific neutral CE hydrolases. The most likely candidate for the hydrolysis of HDL CE delivered via SR-BI in the adrenal gland is hormone sensitive lipase. New data in adrenocortical cells as well as the study of a mutant SR-BI receptor lend insight into the mechanism of cholesterol transfer from plasma HDL to the steroidogenic pathway in endocrine cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources