Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo
- PMID: 15621532
- DOI: 10.1016/j.devcel.2004.12.002
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo
Abstract
The epicardium regulates growth and survival of the underlying myocardium. This activity depends on intrinsic retinoic acid (RA) and erythropoietin signals. However, these signals do not act directly on the myocardium and instead are proposed to regulate the production of an unidentified soluble epicardial derived mitogen. Here, we show that Fgf9, Fgf16, and Fgf20 are expressed in the endocardium and epicardium and that RA can induce epicardial expression of Fgf9. Using knockout mice and an embryonic heart organ culture system, we show that endocardial and epicardial derived FGF signals regulate myocardial proliferation during midgestation heart development. We further show that this FGF signal is received by both FGF receptors 1 and 2 acting redundantly in the cardiomyoblast. In the absence of this signal, premature differentiation results in cellular hypertrophy and newborn mice develop a dilated cardiomyopathy. FGFs thus constitute all or part of the epicardial signal regulating myocardial growth and differentiation.
Similar articles
-
An early Fgf signal required for gene expression in the zebrafish hindbrain primordium.Brain Res Dev Brain Res. 2004 Jan 31;148(1):27-42. doi: 10.1016/j.devbrainres.2003.10.005. Brain Res Dev Brain Res. 2004. PMID: 14757516
-
Gradients of cone differentiation and FGF expression during development of the foveal depression in macaque retina.Vis Neurosci. 2005 Jul-Aug;22(4):447-59. doi: 10.1017/S0952523805224069. Vis Neurosci. 2005. PMID: 16212702
-
Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina.J Neurosci Res. 2005 Feb 1;79(3):329-39. doi: 10.1002/jnr.20363. J Neurosci Res. 2005. PMID: 15614790
-
Heart-specific expression of FGF-16 and a potential role in postnatal cardioprotection.Cytokine Growth Factor Rev. 2015 Feb;26(1):59-66. doi: 10.1016/j.cytogfr.2014.07.007. Epub 2014 Jul 21. Cytokine Growth Factor Rev. 2015. PMID: 25106133 Review.
-
FGF/FGFR signaling in bone formation: progress and perspectives.Growth Factors. 2012 Apr;30(2):117-23. doi: 10.3109/08977194.2012.656761. Epub 2012 Feb 1. Growth Factors. 2012. PMID: 22292523 Review.
Cited by
-
The Multifunctional Contribution of FGF Signaling to Cardiac Development, Homeostasis, Disease and Repair.Front Cell Dev Biol. 2021 May 14;9:672935. doi: 10.3389/fcell.2021.672935. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34095143 Free PMC article. Review.
-
Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression.Open Biol. 2022 Sep;12(9):210356. doi: 10.1098/rsob.210356. Epub 2022 Sep 14. Open Biol. 2022. PMID: 36102060 Free PMC article. Review.
-
The Fibroblast Growth Factor signaling pathway.Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):215-66. doi: 10.1002/wdev.176. Epub 2015 Mar 13. Wiley Interdiscip Rev Dev Biol. 2015. PMID: 25772309 Free PMC article. Review.
-
FGF/FGFR signaling in health and disease.Signal Transduct Target Ther. 2020 Sep 2;5(1):181. doi: 10.1038/s41392-020-00222-7. Signal Transduct Target Ther. 2020. PMID: 32879300 Free PMC article. Review.
-
FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development.Mol Cell Endocrinol. 2013 May 22;371(1-2):182-8. doi: 10.1016/j.mce.2013.01.014. Epub 2013 Jan 29. Mol Cell Endocrinol. 2013. PMID: 23376610 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
