Review
[Regulation of bone mineralization by enzymes]
[Article in
Japanese]
Affiliations
- PMID: 15577050
Item in Clipboard
Review
[Regulation of bone mineralization by enzymes]
[Article in
Japanese]
Clin Calcium.
2004 Jun.
Abstract
The enzymes, such as TNSALP regulate bone mineralization, and the mineralization inhibitor inorganic pyrophosphate (PPi) plays a central role in the process. NPP1 and ANK increase PPi concentration in the extracellular matrix, while TNSALP hydrolyzes PPi. The analyses using knock-out mice demonstrated that NPP1 and ANK, and TNSALP are antagonistic regulators for PPi. Concerted regulation of PPi by TNSALP, NPP1, and ANK, leads bone mineralization to be regulated strictly.
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