Comment
doi: 10.1016/j.immuni.2004.11.001.
Antigen-driven T cell expansion: affinity rules
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- PMID: 15539146
- DOI: 10.1016/j.immuni.2004.11.001
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Comment
Antigen-driven T cell expansion: affinity rules
Immunity.
2004 Nov.
Free article
Abstract
TCR affinity and ligand off-rate have both been found to influence the degree of T cell activation by peptide-MHC. A report in this issue of Immunity finds that ligand off-rate does not correlate with antigen-specific peripheral T cell expansion. Moreover, the data point to the surprising notion that there exist TCR affinity thresholds and, once attained, T cells with higher affinity receptors have no competitive advantage.
Comment on
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Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties.Immunity. 2004 Nov;21(5):669-79. doi: 10.1016/j.immuni.2004.09.008. Immunity. 2004. PMID: 15539153
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