A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion
- PMID: 1552944
- DOI: 10.1038/356248a0
A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion
Abstract
The union of sperm and egg is a special membrane fusion event that gives a signal to begin development. We have hypothesized that proteins mediating cell-cell fusion events resemble viral fusion proteins and have shown that PH-30, a sperm surface protein involved in sperm-egg fusion, shares biochemical characteristics with viral fusion proteins. We report here the complementary DNA and deduced amino-acid sequences of the mature alpha and beta subunits of PH-30. Both are type-I integral membrane glycoproteins. The alpha subunit contains a putative fusion peptide typical of viral fusion proteins and the beta subunit contains a domain related to a family of soluble integrin ligands found in snake venoms. Thus, the PH-30 alpha/beta complex resembles many viral fusion proteins in both its membrane topology and its predicted binding and fusion functions.
Comment in
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A family of fusion proteins.Nature. 1992 Mar 19;356(6366):196-7. doi: 10.1038/356196a0. Nature. 1992. PMID: 1552937 No abstract available.
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