doi: 10.1126/science.1101678.
Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
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- PMID: 15514160
- DOI: 10.1126/science.1101678
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Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
Science.
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Abstract
Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown. Transient inhibition of 5-HTT during early development with fluoxetine, a commonly used serotonin selective reuptake inhibitor, produced abnormal emotional behaviors in adult mice. This effect mimicked the behavioral phenotype of mice genetically deficient in 5-HTT expression. These findings indicate a critical role of serotonin in the maturation of brain systems that modulate emotional function in the adult and suggest a developmental mechanism to explain how low-expressing 5-HTT promoter alleles increase vulnerability to psychiatric disorders.
Comment in
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Neuroscience. Prozac treatment of newborn mice raises anxiety.Science. 2004 Oct 29;306(5697):792. doi: 10.1126/science.306.5697.792. Science. 2004. PMID: 15514122 No abstract available.
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