doi: 10.1055/s-2004-832632.
Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors
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- PMID: 15490334
- DOI: 10.1055/s-2004-832632
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Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors
Planta Med.
2004 Oct.
Abstract
In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.
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