Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2004 Sep;49(9):1433-7.
doi: 10.1023/b:ddas.0000042242.22898.d9.

Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease

Ioannis E Koutroubakis  1 , Niki Malliaraki, Philippos D Dimoulios, Konstantinos Karmiris, Elias Castanas, Elias A Kouroumalis
Affiliations
Comparative Study

Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease

Ioannis E Koutroubakis et al. Dig Dis Sci. 2004 Sep.

Abstract

Oxidative stress and depletion of antioxidants may play a key role in the pathogenesis of inflammatory bowel disease (IBD)-related intestinal damage. A new automated assay for the determination of blood total antioxidant capacity (TAC), based on the crocin bleaching method, has been used for the measurement of TAC and corrected TAC (cTAC) in patients with ulcerative colitis (UC) and Crohn's disease (CD) in comparison to healthy controls (HC). Ninety-four patients with UC, 97 patients with CD, and 72 HC were included in this study. Serum TAC was measured in all patients and controls on an Olympus AU-600 chemistry analyzer using a TAC kit. cTAC was calculated from TAC after subtraction of the interactions due to endogenous uric acid, bilirubin and albumin. Mean serum TAC as well as cTAC levels were significantly lower in both UC and CD patients compared with HC (P < 0.0001). Patients with active UC had no different TAC and cTAC compared to those with inactive disease. Patients with active CD had significantly lower mean TAC compared to those with inactive disease but cTAC was not different between the two phases of disease activity. Patients with proctitis had significantly higher TAC and cTAC compared to patients with left-sided colitis and total colitis. In CD patients no association between disease localization and these markers was found. TAC and cTAC are significantly reduced in IBD patients compared with controls irrespective of disease activity. The decreased antioxidant defenses may be a primary phenomenon severely compromising the mucosa and therefore increase susceptibility to oxidative tissue damage.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Free Radic Res. 1995 Feb;22(2):131-43 - PubMed
    1. J Pathol. 2003 Sep;201(1):17-27 - PubMed
    1. Biochem Med Metab Biol. 1994 Dec;53(2):87-91 - PubMed
    1. J Pathol. 2003 Sep;201(1):28-36 - PubMed
    1. Dig Dis Sci. 2000 Sep;45(9):1814-9 - PubMed

Publication types

MeSH terms

LinkOut - more resources