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. 2004 Oct 14;44(2):251-61.
doi: 10.1016/j.neuron.2004.09.028.

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

Nuria Flames  1 , Jason E Long, Alistair N Garratt, Tobias M Fischer, Martin Gassmann, Carmen Birchmeier, Cary Lai, John L R Rubenstein, Oscar Marín
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Free article

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1

Nuria Flames et al. Neuron. .
Free article

Abstract

Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified. Here, we show that different isoforms of Neuregulin-1 are expressed in the developing cortex and in the route that migrating interneurons follow toward the cortex, whereas a population of the migrating interneurons express ErbB4, a receptor for Neuregulin-1. The different isoforms of Neuregulin-1 act as short- and long-range attractants for migrating interneurons, and perturbing ErbB4 function in vitro decreases the number of interneurons that tangentially migrate to the cortex. In vivo, loss of Neuregulin-1/ErbB4 signaling causes an alteration in the tangential migration of cortical interneurons and a reduction in the number of GABAergic interneurons in the postnatal cortex. These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system.

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