Review
doi: 10.1038/nri1457.
IDO expression by dendritic cells: tolerance and tryptophan catabolism
Affiliations
- PMID: 15459668
- DOI: 10.1038/nri1457
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Review
IDO expression by dendritic cells: tolerance and tryptophan catabolism
Nat Rev Immunol.
2004 Oct.
Abstract
Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.
Comment in
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Literature watch: implications for transplantation. AHR and tryptophan catabolism: putting the effector T-cell response to sleep.Am J Transplant. 2012 Apr;12(4):801. doi: 10.1111/j.1600-6143.2012.04058.x. Am J Transplant. 2012. PMID: 22458381 No abstract available.
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