Migration pathways and immunologic memory among T lymphocytes
- PMID: 1534264
Migration pathways and immunologic memory among T lymphocytes
Abstract
The lymphatic and circulatory systems are essential channels for the dissemination of memory cells throughout the body. However, the migration of naive and memory T cells through these channels is not random. Naive-type T cells preferentially migrate from blood to lymph nodes whereas memory T cells preferentially migrate to tissues, particularly those with a high exposure to antigen. The large-scaled migration of naive T cells through lymph nodes increases the likelihood of these T cells encountering a primary antigen, and brings them in contact with other players, particularly antigen presenting cells. On the other hand, the migration of memory T cells to tissues such as skin or gut mucosa serves to provide an immediate protection in an environment where antigen is likely to be re-encountered. The migration of memory T cells is further rationalized, in that phenotypically distinct subsets of memory T cells migrate to specific tissues. The migration of lymphocytes through the body is controlled by adhesion molecules on the surface of lymphocytes, which interact with receptors on the surface of endothelium, and it is the differential expression of these molecules which in part controls the different migration streams of T cells through the body.
Similar articles
-
Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells.Eur J Immunol. 1992 Apr;22(4):887-95. doi: 10.1002/eji.1830220402. Eur J Immunol. 1992. PMID: 1372559
-
Differential expression of homing-associated adhesion molecules by T cell subsets in man.J Immunol. 1990 Nov 15;145(10):3247-55. J Immunol. 1990. PMID: 1700003
-
The migratory behavior of murine CD4+ cells of memory phenotype.Eur J Immunol. 1997 Sep;27(9):2225-32. doi: 10.1002/eji.1830270916. Eur J Immunol. 1997. PMID: 9341763
-
Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues.Mol Immunol. 2005 May;42(7):799-809. doi: 10.1016/j.molimm.2004.06.040. Epub 2004 Nov 23. Mol Immunol. 2005. PMID: 15829268 Review.
-
Function of CD4 T cell subsets in vivo: expression of CD45R isoforms.Semin Immunol. 1992 Feb;4(1):43-50. Semin Immunol. 1992. PMID: 1534263 Review.
Cited by
-
In vivo persistence of expanded clones specific for bacterial antigens within the human T cell receptor alpha/beta CD4-8- subset.J Exp Med. 1993 Jun 1;177(6):1763-71. doi: 10.1084/jem.177.6.1763. J Exp Med. 1993. PMID: 7684433 Free PMC article.
-
CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rodents migrate to the recipient's colon upon transfer; down-regulation by CD8+ T cells.Clin Exp Immunol. 1998 May;112(2):216-25. doi: 10.1046/j.1365-2249.1998.00564.x. Clin Exp Immunol. 1998. PMID: 9649183 Free PMC article.
-
Distribution, persistence and interchange of Epstein-Barr virus strains among PBMC, plasma and saliva of primary infection subjects.PLoS One. 2015 Mar 25;10(3):e0120710. doi: 10.1371/journal.pone.0120710. eCollection 2015. PLoS One. 2015. PMID: 25807555 Free PMC article.
-
Activation and differentiation requirements of primary T cells in vitro.Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8987-91. doi: 10.1073/pnas.90.19.8987. Proc Natl Acad Sci U S A. 1993. PMID: 8415642 Free PMC article.
-
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy.Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13193-7. doi: 10.1073/pnas.94.24.13193. Proc Natl Acad Sci U S A. 1997. PMID: 9371822 Free PMC article.