Review
doi: 10.1038/nrd1500.
Biochemical mechanisms of drug action: what does it take for success?
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- PMID: 15340390
- DOI: 10.1038/nrd1500
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Review
Biochemical mechanisms of drug action: what does it take for success?
Nat Rev Drug Discov.
2004 Sep.
Abstract
Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks.
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