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. 2004 Sep;59(9):769-72.
doi: 10.1136/thx.2003.012930.

Antitussive activity of iodo-resiniferatoxin in guinea pigs

M Trevisani  1 , A Milan, R Gatti, A Zanasi, S Harrison, G Fontana, A H Morice, P Geppetti
Affiliations

Antitussive activity of iodo-resiniferatoxin in guinea pigs

M Trevisani et al. Thorax. 2004 Sep.

Abstract

Background: Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1).

Methods: The ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants (capsaicin and citric acid) was tested in non-anaesthetised guinea pigs.

Results: Pretreatment with I-RTX either intraperitoneally (0.03-0.3 micromol/kg) or by aerosol (0.1-3 microM) reduced the number of coughs produced by inhalation of citric acid (0.25 M) and capsaicin (30 microM) in a dose dependent manner. Capsazepine (CPZ) also reduced citric acid and capsaicin induced cough, but the activity of I-RTX was 10-100 times more potent than CPZ in all the experimental conditions tested.

Conclusions: I-RTX is a novel and potent antitussive drug which inhibits cough mediated by agents possibly acting via TRPV1 activation.

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Comment in

  • TRPV1 and cough.
    Anderson GP. Anderson GP. Thorax. 2004 Sep;59(9):730-1. doi: 10.1136/thx.2003.016782. Thorax. 2004. PMID: 15333843 Free PMC article. No abstract available.

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